Organonitrogen Compounds
Medchemexpress LLC PF-562271 besylate | 939791-38-5 | MFCD14105612 | 99.2% | 665.66 | C27H26F3N7O6S2 | 50 MG
PF-562271 besylate is the besylate salt of a potent, ATP-competitive, reversible inhibitor of focal adhesion kinase (FAK) and Pyk2 commonly used in preclinical biochemical and cellular research. It shows low-nanomolar activity against FAK and is supplied at high purity in small-scale packages for laboratory studies.
- Potent ATP-competitive inhibitor of FAK and Pyk2 (FAK IC50 ≈ 1.5 nM; Pyk2 IC50 ≈ 13 nM).
- Reversible mechanism suitable for biochemical assays.
- High purity for research applications (reported ~99.17%).
- Available in multiple small-scale package sizes for laboratory use.
- Suitable for cellular and signaling pathway studies.
Selleck Chemical LLC Nimodipine S1747-1g
Nimodipine (BAY E 9736) is a dihydropyridine calcium channel blocker and an autophagy inhibitor used in the treatment of high blood pressure
Sigma Aldrich Fine Chemicals Biosciences Nicardipine hydrochloride United States Pharmacopeia (USP) Reference Standard | 54527-84-3 | MFCD00057327 | 200MG
Nicardipine hydrochloride United States Pharmacopeia (USP) Reference Standard | Mol Wt: 515.99 | 54527-84-3 | MFCD00057327 | 200MG
Medchemexpress LLC PF-562271 besylate | 939791-38-5 | MFCD14105612 | 99.2% | 665.66 g/mol | C27H26F3N7O6S2 | 1 ML
PF-562271 besylate is a potent, ATP-competitive, reversible inhibitor of focal adhesion kinase (FAK) and Pyk2 used in biochemical, cell-based, and in vivo research. It is supplied as a 10 mM solution in DMSO and exhibits low-nanomolar activity against FAK and nanomolar activity against Pyk2.
- Potent inhibition of FAK and Pyk2 (FAK IC50 = 1.5 nM; Pyk2 IC50 = 13 nM).
- Supplied as a ready-to-use 10 mM solution in DMSO for in vitro assays.
- High reported purity suitable for research use (99.17%).
- Demonstrated antiproliferative activity across multiple cancer cell lines.
- Validated pharmacological effects in vivo, including inhibition of FAK phosphorylation.
Med Vet International AmLodipine, 10mg Tablets, 1000 Count
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Amlodipine, 10mg Tablets, 1000 Count
Medchemexpress LLC (R)-Nimodipine ((R)-BAY-e 9736) | 77940-92-2 | 99.9% | 5 MG
(R)-Nimodipine ((R)-BAY-e 9736) | 77940-92-2 | 99.9% | 5 MG
Medchemexpress LLC Nimodipine (BAY-e 9736) | 66085-59-4 | 99.9% | 1 G
Nimodipine (BAY-e 9736) is an orally active, well-tolerated, and light-sensitive dihydropyridine calcium antagonist. It can be used for the research of cerebrovascular disorders.
- Orally active
- Well-tolerated
- Light-sensitive
- Dihydropyridine calcium antagonist
- Used for the research of cerebrovascular disorders
Apexbio Technology LLC Amlodipine Besylate 111470-99-6 10mM (in 1mL DMSO)
Amlodipine Besylate (CAS 111470-99-6) is a long-acting calcium channel blocker that reduces blood pressure primarily through inhibition of calcium ion influx via voltage-gated calcium channels Calcium channel modulation influences critical cellular signaling pathways In cortical neurons exposed to oxidative stress Amlodipine Besylate ( 5 M) preserves cellular viability by reducing oxidative damage enhancing pro-survival signals and suppressing apoptotic pathways It has also demonstrated proliferative effects on human epidermoid carcinoma (A431) cells Furthermore clinical studies indicate that Amlodipine Besylate decreases peripheral vascular resistance and myocardial oxygen demand in angina patients and effectively lowers arterial pressure in hypertensive feline models
Medchemexpress LLC To-1187 TFA | 98.4% | 795.72 | 100 MG
TO-1187 TFA is a selective HDAC6 PROTAC degrader with a DC50 of 5.81 nM. It functions by promoting the ubiquitination and degradation of HDAC6 and can be used in the study of hematological malignancies and solid tumors. The compound is described as being composed of an HDAC6 ligand (HY-173386), a CRBN ligase ligand (HY-41547), and a linker (HY-140212).
- Selective HDAC6 PROTAC degrader (DC50: 5.81 nM).
- Promotes the ubiquitination and degradation of HDAC6.
- Applicable in the study of hematological malignancies and solid tumors.
Medchemexpress LLC To-1187 (TFA) | 98.4% | 795.72 | 50 MG
TO-1187 TFA is a selective HDAC6 PROTAC degrader with a DC50 of 5.81 nM. It functions by promoting the ubiquitination and degradation of HDAC6. This compound is suitable for use in research studying hematological malignancies and solid tumors. The compound is composed of an HDAC6 ligand, a CRBN ligase ligand, and a linker.
- Selective HDAC6 PROTAC degrader, exhibits a DC50 of 5.81 nM, indicating potent and specific degradation of HDAC6.
- Promotes ubiquitination and subsequent degradation of HDAC6.
- Useful in the study of hematological malignancies and solid tumors.
- Consists of a specific HDAC6 ligand, a CRBN ligase ligand, and a linker.
- Purity of 98.41%.
Medchemexpress LLC PF-562271 besylate | 939791-38-5 | MFCD14105612 | 99.2% | 665.7 g/mol | C27H26F3N7O6S2 | 1 MG
PF-562271 besylate is an ATP-competitive, reversible inhibitor of focal adhesion kinase (FAK) and proline-rich tyrosine kinase 2 (Pyk2) used as a research tool in cell-signaling and oncology studies. It exhibits potent biochemical activity (FAK IC50 ≈ 1.5 nM; Pyk2 IC50 ≈ 13-14 nM), is supplied as the besylate salt, and is available at high purity for in vitro and in vivo research.
- Potent ATP-competitive, reversible inhibitor of FAK and Pyk2.
- Low nanomolar biochemical potency for target kinases.
- Provided as a besylate salt for improved stability and handling.
- High reported purity suitable for research applications.
- Used in cellular and animal model studies of tumor signaling pathways.
Accela Chembio Inc Isopropyl 3-aminocrotonate | 100g | 14205-46-0 | MFCD00134272 | 97+% | Shelf Life: 1260 Days | Light Sensitive/+4
Isopropyl 3-aminocrotonate | 100g | 14205-46-0 | MFCD00134272 | 97+% | Shelf Life: 1260 Days | Light Sensitive/+4
Apexbio Technology LLC Cisatracurium Besylate 96946-42-8 10mM (in 1mL DMSO)
Cisatracurium Besylate (CAS 96946-42-8) is a non-depolarizing neuromuscular blocking agent that acts by competitively inhibiting acetylcholine at nicotinic receptors on the neuromuscular junction This inhibition prevents depolarization of the muscle cell membrane resulting in skeletal muscle relaxation Cisatracurium Besylate is utilized in biomedical research to study neuromuscular transmission skeletal muscle function and mechanisms underlying muscle paralysis It is also frequently used as an adjunct in anesthesia research to model conditions requiring controlled muscle relaxation such as intubation or mechanical ventilation